The article analyzes the main factors, which determined the process of Christianization of indigenous people, living in a big region from the Enisey to the Pacific Ocean. Unfinished annexation of the region to the territory of Russia caused paucity of Russians, persistent scarcity of perish clergy, lack of trained missionaries and preachers, conflict of interests of the Russian Orthodox Church and Soviet authorities. Abuse of power of the local civil and religious authorities made think of the supreme power as an utopian idea. Even the general Christianization would not be sufficient to make Siberian area an integral part of Russia and consolidate the territory. Strong ethnic and religious tolerance typical for Russian people, commoners in particular, and positive complеmentarity of the ancient Asian peoples, liable to pay fur tributes, gradually brought them closer together, especially through Christianization. At the end of the XVIIIth century there were 20–25 % of Christianized. It resulted in a positive model of further selfdevelopment of most peoples of Eastern Siberia.